The important active alkaloids in Kratom are mitragynine and 7-hydroxymitragynine. These alkaloids are responsible for pain relieving, sedative, euphoric, and stimulating effects.
There are very few reports regarding negative health effects due to Kratom and the circumstances reported were in conjunction with additional illegal substances combined, so there is no conclusive data showing Kratom as the cause for any negative effects.
Health problems are unlikely unless one is consuming large quantities of Kratom every day.
In Thailand, where many of the indigenous population use Kratom daily, those dependent on it can develop weight loss and have physical withdrawal symptoms when quitting abruptly. If any, the withdrawal symptoms may include muscle aches, irritability, crying, runny nose, diarrhea, and muscle jerking. Health problems are unlikely to occur in occasional Kratom users.
Like any drug or medicine, moderation is the key and individual’s reactions may vary. It is uncommon, but an individual could possibly experience an allergic or other unusual reaction to Kratom, even if used responsibly. More commonly, when using an excessive amount, an individual’s body would simply reject the substance, thus as a natural physiological reaction, may experience emesis (Vomiting) as the body’s way of preservation.
Kratom is quite unique, in that, in low to moderate doses will commonly be stimulating and in large doses has a more sedative effect. Often, the individual will experience an analgesic effect caused by the alkaloids contained in Kratom and the manner in which the brain receptors are affected. The level of effect, like any other supplement, depends on many factors including body weight, physiological makeup, tolerance level and so on.
As a stimulant, used in low to moderate doses, the individual will experience an analgesic effect along with physical energy, alertness, increased libido, euphoria, sociability, improved mindset or mood, focus and overall improved demeanor. In some cases when taken in large doses, an individual may experience edginess similar to being over-caffeinated.
An a sedative, used in higher doses, an individual will experience an analgesic effect along with euphoria, a lower sensitivity to pain, both physically and emotionally, relaxation, anti-depression and anti-anxiety. Used in excess, it may result in a prolonged sleep.
Although a small number of individuals have become dependent on Kratom (primarily in Thailand), Kratom is not habit forming when used in moderation and responsibly. When used in moderation, not daily, there is no documented risk of dependency. It is important not to get into the habit of using Kratom, or any supplement, on a daily basis. Like many stimulants [e.g. alcohol, coffee, tobacco, etc.], when used daily for a prolonged period of time, could become habit forming. You know your body better than any physician and must be diligent regarding self control. If you have a predisposition for addiction, you must treat everything with moderate behavior including the use of Kratom.
When taken by itself (not mixing it with other substances), the greatest risk when taking Kratom may be falling asleep while engaged in hazardous activities. Like any other substance that may be mind altering or affect your cognitive abilities, do not drive or operate heavy machinery while under the influence of Kratom. Always use common sense. Due to the lack of medical studies regarding the use of Kratom in relation to pregnancy, pregnant women should not take any drug or medication except at the medical advice from their physician. It is not known whether it could cause birth defects or fetal death. Once again, always use common sense regarding anything that you put in your body.
Here are a few resources regarding Kratom that you might find useful.
This has some good information regarding what Kratom (Mitragyna speciosa) is and it’s properties.
A great online resource of Kratom enthusiasts and community members. This is one of the better resources for new and old Kratom users alike.
US Department of Health and Human Services
The United States Department of Health and Human Services (HHS.gov), also known as the Health Department, is a cabinet-level department of the U.S. federal government with the goal of protecting the health of all Americans and providing essential human services.
US Food and Drug Administration
The Food and Drug Administration is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
Kratom Eight Factor Study and Recommendations
AKA sponsored Eight Factor Study including recommendations conducted by Pinney Associates – Assessment of Kratom under the CSA Eight Factors and Scheduling Recommendation November 28, 2016.
These statements have not been evaluated by the Food & Drug Administration. Kratom is not intended to diagnose, treat, cure or prevent any disease. Consult your healthcare professional prior to use if you have or suspect a medical condition. If you are under medical supervision, are using anti-depressants, anti-anxiety medications, diabetes medications, narcotics, blood pressure medication, sedatives, tranquilizers or asthma medication, seek the advice of your healthcare professional prior to use. Do not use if you are pregnant, lactating or under the age of 18 years. Do not take when operating machinery or driving. Keep out of reach of children.